When the Borg return, Captain Picard must do the unthinkable to attempt to stop them before the new queen awakens: turn himself into Locutus once again.  Meanwhile, Worf, struggling with his decision to sacrifice a mission to save the life of his wife, turns down a promotion to become the new first officer of the Enterprise, but must take command when Picard is re-assimilated by the Borg.  Can he subvert the expectations of his captain to come up with a way to save him and stop the Borg from advancing against humanity and the Earth?

J.M. Dillard, author of many a Star Trek movie novelization, helps to set up a new status quo for the Enterprise E following the aftermath of Star Trek: Nemesis in Resistance.  With Riker and Troi off to a new ship and Data destroyed, Dillard introduces a new, yet familiar first officer, a new counselor, and starts to round out the senior staff with new characters who will propel the future novels set in this universe.